NU-8231

Names

[ Name ]:
NU-8231

Biological Activity

[Description]:

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay; induces p53-dependent gene transcription SJSA human sarcoma cell line.

[References]

References 1. Hardcastle IR, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1515-20. 2. Hardcastle IR, et al. J Med Chem. 2011 Mar 10;54(5):1233-43. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₆ClNO₅

[ Molecular Weight ]:
467.95

Related Compounds

NU 2058
NU 9056
NU-8165
NU 6140
NU-7163
NU1025
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
QUERCETIN 3-O-beta-D-GLUCURONIDE METHYL ESTER
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
N-(5-Chloro-2,4-dimethoxyphenyl)-3-thiophenemethanamine
tert-Butyl-DL-alanine