2-Nitrochlorobenzene
Names
[ CAS No. ]:
88-73-3
[ Name ]:
2-Nitrochlorobenzene
[Synonym ]:
2-Nitrochlorobenzene
1-Chloro-2-nitro-benzene
ortho-chloronitrobenzene
1-Nitro-2-chlorobenzene
benzene, chloronitro-
chloronitrobenzene
MFCD00007061
EINECS 201-854-9
nitrochlorobenzene
Nitrochlorobenzene, o-
o-chloronitrobenzene
o-Nitrochlorobenzene
Benzene, 1-chloro-2-nitro-
2-CHLORO-1-NITROBENZENE
1-chloronitrobenzene
Nitrochlorobenzene, ortho
1-Chloro-2-nitrobenzene
2-Chloronitrobenzene
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
245.5±0.0 °C at 760 mmHg
[ Melting Point ]:
31-33 °C(lit.)
[ Molecular Formula ]:
C6H4ClNO2
[ Molecular Weight ]:
157.555
[ Flash Point ]:
96.5±19.8 °C
[ Exact Mass ]:
156.993057
[ PSA ]:
45.82000
[ LogP ]:
2.34
[ Vapour density ]:
5.4 (vs air)
[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.580
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
[ Water Solubility ]:
0.43 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CZ0875000
- CHEMICAL NAME :
- Benzene, 1-chloro-2-nitro-
- CAS REGISTRY NUMBER :
- 88-73-3
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C6-H4-Cl-N-O2
- MOLECULAR WEIGHT :
- 157.56
- WISWESSER LINE NOTATION :
- WNR BG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 268 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/m3/6H/4W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 ppb/6H/13W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 ppm/6H/2W-C
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2300 ppb/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 gm/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 18 ppm/6H
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 4500 ppb/6H
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4011 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2897 (estimated) No. of Female Employees: 662 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311
[ Precautionary Statements ]:
P280-P301 + P310-P312
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R22;R24;R52/53
[ Safety Phrases ]:
S36/37/39-S45-S60-S38-S28A
[ RIDADR ]:
UN 1578 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
CZ0875000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29049085
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2904901100
[ Summary ]:
2904901100 1-chloro-2-nitrobenzene. Supervision conditions:None.VAT:17.0% Tax rebate rate:9.0%
Articles
Arch. Dermatol. 124(3) , 396-8, (1988)
2,4-Dinitrochlorobenzene (DNCB) is used for immunotherapy of alopecia areata and verruca vulgaris. We initially postulated that the presence of mutagenic contaminants in commercially available DNCB mi...
Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.J. Chromatogr. A. 1361 , 217-28, (2014)
Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substanc...
2-Chloronitrobenzene, 3-chloronitrobenzene and 4-chloronitrobenzene.IARC Monogr. Eval. Carcinog. Risks Hum. 65 , 263-96, (1996)