Benzene,1,3-bis(trichloromethyl)-

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C8-H4-Cl6

MOLECULAR WEIGHT :

312.82

WISWESSER LINE NOTATION :

GXGGR CXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,308,1969 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2924 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

5700 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Kidney, Ureter, Bladder - urine volume increased

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 29(11),51,1985 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2129 mg/kg

SEX/DURATION :

male 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :

GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2129 mg/kg

SEX/DURATION :

female 26 week(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :

GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967- Volume(issue)/page/year: 21,34,1982