4-Azidobutylamine

Names

[ Name ]:
4-Azidobutylamine

[Synonym ]:
6-azidobutylamine
4-Azido-1-butanamine
1-amino-4-azidobutane
4-azido-1-butylamine
1-azido-4-aminobutane
4-azido-butylamine
1-Butanamine,4-azido

Biological Activity

[Description]:

4-Azidobutylamine is a PROTAC linker, which refers to the alkyl chain composition. 4-Azidobutylamine can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

[2]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₁₀N₄

[ Molecular Weight ]:
114.14900

[ Exact Mass ]:
114.09100

[ PSA ]:
75.77000

[ LogP ]:
1.18866

MSDS

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Safety Information

[ HS Code ]:
2929909090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%