Heclin

Names

[ Name ]:
Heclin

[Synonym ]:
Heclin
2-Propenamide, N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-, (2E)-
(2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide
N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Biological Activity

[Description]:

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.

[References]

References 1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. View Related Products by Target E3 Ubiquitin Ligase

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
495.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇NO₃

[ Molecular Weight ]:
283.322

[ Flash Point ]:
253.4±28.7 °C

[ Exact Mass ]:
283.120850

[ LogP ]:
4.22

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport