Verdiperstat

Names

[ Name ]:
Verdiperstat

[Synonym ]:
MFCD30533444

Biological Activity

[Description]:

Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

IC50: 630 nM (Myeloperoxidase)[1]

[In Vitro]

Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders[1]. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation[2].

[References]

[1]. Johnström P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60.

[2]. Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.

[Related Small Molecules]

RSL3 | AZD5904 | PF-06282999 | Tinoridine hydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₃O₂S

[ Molecular Weight ]:
253.32

[ Storage condition ]:
-20℃