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T-521

Names

[ CAS No. ]:
891020-54-5

[ Name ]:
T-521

[Synonym ]:
5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole
Oxazole, 5-(ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-

Biological Activity

[Description]:

T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3; impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells; suppresses the growth of A549 cells in xenograft nude mice.

[References]

References 1. Chen Y, et al. Oncotarget. 2017 Jan 3;8(1):1234-1246. View Related Products by Target Polo-like Kinase (PLK)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
637.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H27Cl2N5O2

[ Molecular Weight ]:
395.425

[ Flash Point ]:
339.2±34.3 °C

[ Exact Mass ]:
395.029755

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.578

Related Compounds