Aceclofenac

Names

[ Name ]:
Aceclofenac

[Synonym ]:
Acelofenac
Aceclofenac
EINECS 205-783-4
Aceclofar
Preservex
MFCD00864296
Falcol
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}acetoxy)acetic acid
Tresquim
Biofenac
Zerodol
Airtal
PR-82/3
Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester
Gerbin

Biological Activity

[Description]:

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

COX-2:3 μM (IC50)

COX-1:7.3 μM (IC50)

[References]

[1]. Dannhardt G, et al. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001 May;50(5):262-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
486.0±45.0 °C at 760 mmHg

[ Melting Point ]:
149-153°C

[ Molecular Formula ]:
C₁₆H₁₃Cl₂NO₄

[ Molecular Weight ]:
354.185

[ Flash Point ]:
247.8±28.7 °C

[ Exact Mass ]:
353.022156

[ PSA ]:
75.63000

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.639

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1577900

CHEMICAL NAME :: Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, carboxymethyl ester

CAS REGISTRY NUMBER :: 89796-99-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H13-Cl2-N-O4

MOLECULAR WEIGHT :: 354.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1265,1991

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319-H410

[ Precautionary Statements ]:
P273-P301 + P310-P305 + P351 + P338-P501

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ Hazard Class ]:
6.1

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Development and implication of methodology for aceclofenac in pure and pharmaceutical formulations by microwave assisted spectrophotometry.

Pak. J. Pharm. Sci. 26(1) , 169-73, (2013)

A simple, fast and cost effective method for determination of aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured com...

Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

Int. J. Pharm. 438(1-2) , 117-22, (2012)

Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal a...

Absolute bioavailability and metabolism of aceclofenac in rats.

Arch. Pharm. Res. 38(1) , 68-72, (2015)

Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac h...