D-Amino acid oxidase

Names

[ Name ]:
D-Amino acid oxidase

[Synonym ]:
d-aao
EINECS 232-563-5
d-amino acid:oxygen oxidoreductase
d-amino acid oxidase, immobilized
ec 1.4.3.3
d-amino acid oxidase tv
d-amino acid : oxygen oxidoreductase (deaminating)
d-amino acid oxidase
d-amino acid oxidase, carrier-fixed
MFCD00081546

Biological Activity

[Description]:

D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Pilone MS. D-Amino acid oxidase: new findings. Cell Mol Life Sci. 2000 Nov;57(12):1732-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₀N₂O₂

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ RIDADR ]:
NONH for all modes of transport

Articles

Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.

JAMA Psychiatry 70(12) , 1267-75, (2013)

In addition to dopaminergic hyperactivity, hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has an important role in the pathophysiology of schizophrenia. Enhancing NMDAR-mediated neurotransm...

D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.

Amino Acids 43(5) , 1811-21, (2012)

D-Amino acids are stereoisomers of L-amino acids. They are often called unnatural amino acids, but several D-amino acids have been found in mammalian brains. Among them, D-serine is abundant in the fo...

Brain D-amino acids: a novel class of neuromodulators.

Amino Acids 43(5) , 1809-10, (2012)