Collagenase

Names

[ Name ]:
Collagenase

[Synonym ]:
EINECS 232-582-9
MFCD00130830
D-Arginine, 1-[[[4-[(E)-2-phenyldiazenyl]phenyl]methoxy]carbonyl]-L-prolyl-L-leucylglycyl-L-prolyl-, hydrate (1:2)
1-[({4-[(E)-Phenyldiazenyl]benzyl}oxy)carbonyl]-L-prolyl-L-leucylglycyl-L-prolyl-D-arginine dihydrate
Collagenase

Biological Activity

[Description]:

Collagenase is a proteolytic enzyme, which breaks the peptide bonds in collagen. Collagenase has good research potential in disc herniation, keloid, cellulite, lipoma, as well as peyronie's disease and dupuytren fracture[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hamzeh Alipour, et al. Therapeutic applications of collagenase (metalloproteases): A review. Asian Pac J Trop Biomed, 2016, 6(11): 975-981.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₅₆N₁₀O₁₀

[ Molecular Weight ]:
812.912

[ Exact Mass ]:
812.418091

[ Appearance of Characters ]:
powder | light brown

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble in aqueous buffers.

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R42/43

[ Safety Phrases ]:
S22;S24;S37;S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells.

Oncotarget 6(2) , 651-61, (2015)

Increased glucose metabolism is now recognized as an emerging hallmark of cancer. Recent studies have shown that glucose metabolism is even more active in cancer stem cells (CSCs), a rare population o...

Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.

Infect. Immun. 83(3) , 1089-103, (2015)

Vibrio cholerae O1 is a major cause of acute watery diarrhea in over 50 countries. Evidence suggests that V. cholerae O1 may activate inflammatory pathways, and a recent study of a Bangladeshi populat...

Fibrin supports human fetal islet-epithelial cell differentiation via p70(s6k) and promotes vascular formation during transplantation.

Lab. Invest. 95 , 925-36, (2015)

The human fetal pancreas expresses a variety of extracellular matrix (ECM) binding receptors known as integrins. A provisional ECM protein found in blood clots that can bind to integrin receptors and ...