Glucose oxidase

Names

[ Name ]:
Glucose oxidase

[Synonym ]:
beta-D-Glucose:quinone oxidoreductase
(2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic Acid 3,4-Lactone
Alfamalt Gloxyl 4080
4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
DL-Patulin
Mycoin C3
beta-D-Glucose oxidase
Clavacin
Claviformin
EINECS 232-601-0
Penicidin
Clairformin
Patulin
Bakezyme G01500
gigantin
MFCD00131182
Clavatin
Patuline
Claviform
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-

Biological Activity

[Description]:

Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Microbial Metabolite

[In Vitro]

Glucose oxidase is a subset of oxidoreductase enzymes that catalyzes the transfer of electrons from an oxidant to a reductant. Glucose oxidases use oxygen as an external electron acceptor that releases hydrogen peroxide (H2 O2). Glucose oxidase has many applications in commercial processes, including improving the color and taste, increasing the persistence of food materials, removing the glucose from the dried egg, and eliminating the oxygen from different juices and beverages[4].

[References]

[1]. Konishi T, et al. Safety evaluation of glucose oxidase from Penicillium chrysogenum [published correction appears in Regul Toxicol Pharmacol. 2013 Aug;66(3):300]. Regul Toxicol Pharmacol. 2013;66(1):13-23.

[2]. Leskovac V, et al. Glucose oxidase from Aspergillus niger: the mechanism of action with molecular oxygen, quinones, and one-electron acceptors. Int J Biochem Cell Biol. 2005;37(4):731-750.

[3]. Wang M, et al. Recent Advances in Glucose-Oxidase-Based Nanocomposites for Tumor Therapy. Small. 2019;15(51):e1903895.

[4]. Khatami SH, et al. Glucose oxidase: Applications, sources, and recombinant production [published online ahead of print, 2021 Apr 11]. Biotechnol Appl Biochem. 2021;10.1002/bab.2165.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
513.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₂O₆

[ Molecular Weight ]:
154.120

[ Flash Point ]:
226.8±23.6 °C

[ Exact Mass ]:
154.026611

[ LogP ]:
-0.75

[ Appearance of Characters ]:
solution (clear) | yellow

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.603

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H334

[ Precautionary Statements ]:
P261-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
42-36/37/38

[ Safety Phrases ]:
45-22-23-36-26-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
RQ8452000

[ HS Code ]:
35079090

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Far-field optical nanoscopy has been widely used to image small objects with sub-diffraction-limit spatial resolution. Particularly, reversible saturable optical fluorescence transition (RESOLFT) nano...

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