Malate dehydrogenase

Names

[ Name ]:
Malate dehydrogenase

[Synonym ]:
2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid
Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
MFCD00131567
N-(3-Aminopropanoyl)histidine
EINECS 232-622-5

Biological Activity

[Description]:

Malate dehydrogenase catalyzes the mutual conversion of oxaloacetate and malate, and is associated with the oxidation/reduction of dinucleotide coenzymes[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Goward CR, et al. Malate dehydrogenase: a model for structure, evolution, and catalysis. Protein Sci. 1994 Oct;3(10):1883-8.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄N₄O₃

[ Molecular Weight ]:
226.232

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
226.106583

[ LogP ]:
-2.17

[ Appearance of Characters ]:
suspension | slightly beige

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Brucella abortus depends on pyruvate phosphate dikinase and malic enzyme but not on Fbp and GlpX fructose-1,6-bisphosphatases for full virulence in laboratory models.

J. Bacteriol. 196(16) , 3045-57, (2014)

The brucellae are the etiological agents of brucellosis, a worldwide-distributed zoonosis. These bacteria are facultative intracellular parasites and thus are able to adjust their metabolism to the ex...

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal. 2 , ra46, (2009)

Protein phosphorylation events during T cell receptor (TCR) signaling control the formation of complexes among proteins proximal to the TCR, the activation of kinase cascades, and the activation of tr...

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...