Neuraminidase

Names

[ Name ]:
Neuraminidase

[Synonym ]:
2-[(3-Aminopropanoyl)amino]-3-(1H-imidazol-4-yl)propanoic acid
Histidine, β-alanyl-
b-Alanylhistidine
β-Alanylhistidine
carnosine
EINECS 232-624-6
MFCD00131711
N-(3-Aminopropanoyl)histidine

Biological Activity

[Description]:

Neuraminidase (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Shtyrya YA, et al. Influenza virus neuraminidase: structure and function. Acta Naturae. 2009 Jul;1(2):26-32.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄N₄O₃

[ Molecular Weight ]:
226.232

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
226.106583

[ LogP ]:
-2.17

[ Appearance of Characters ]:
lyophilized powder | white

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble in water or 10mM phosphate buffer, pH 6.0

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QQ3450000

Articles

Neuraminidase inhibitors for influenza: a review and public health perspective in the aftermath of the 2009 pandemic.

Influenza Other Respi. Viruses 7 Suppl 1 , 14-24, (2013)

The objectives of this study were to: (1) reflect on key stages in the discovery, development and pre-pandemic use of neuraminidase inhibitors (NAIs), (2) summarise the evidence of NAI effectiveness f...

Genetic ancestor of external antigens of pandemic influenza A/H1N1 virus.

Interdiscip. Sci. 4(4) , 282-90, (2012)

The aim of the present investigation was to discover the genetic relationships of 2009 pandemic novel influenza A/H1N1 virus (NIV) external antigens Hemagglutinin (HA) and Neuraminidase (NA) with othe...

Nucleic acid-based detection of influenza A virus subtypes H7 and N9 with a special emphasis on the avian H7N9 virus.

Euro Surveill. 19(10) , (2014)

In 2013, a novel influenza A virus of subtype H7N9 was transmitted from avian sources to humans in China, causing severe illness and substantial mortality. Rapid and sensitive diagnostic approaches ar...