Clostripain from Clostridium histolyticum
Names
[ CAS No. ]:
9028-00-6
[ Name ]:
Clostripain from Clostridium histolyticum
[Synonym ]:
MFCD00130814
Pyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dione, 9-bromo-4,5,6,10c-tetrahydro-2-phenyl-4-(3,4,5-trimethoxyphenyl)-
9-Bromo-2-phenyl-4-(3,4,5-trimethoxyphenyl)-4,5,6,10c-tetrahydropyrrolo[3,4-c]carbazole-1,3(2H,3aH)-dione
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
751.6±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C29H25BrN2O5
[ Molecular Weight ]:
561.423
[ Flash Point ]:
408.4±32.9 °C
[ Exact Mass ]:
560.094666
[ LogP ]:
4.55
[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C
[ Index of Refraction ]:
1.669
[ Storage condition ]:
2-8°C
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Articles
FEMS Immunol. Med. Microbiol. 45(2) , 137-42, (2005)
Clostridium histolyticum culture supernatant contains numerous enzymes, which exert a cytotoxic effect on host cells. This includes lethal toxin, clostripain and high-potassium-sensitive toxin. Since ...
High-level production and purification of clostripain expressed in a virulence-attenuated strain of Clostridium perfringens.Protein Expr. Purif. 76(1) , 83-9, (2011)
Clostripain (CLO) produced by Clostridium histolyticum is an arginine-specific endopeptidase with the potential for applicability to diverse medical and industrial uses. In this study, we developed an...
Protease-mediated ligation of abiotic oligomers.J. Am. Chem. Soc. 127(49) , 17132-3, (2005)
We demonstrate that proteases can catalyze the ligation of peptidomimetic oligomers. The enzyme clostripain was used to facilitate the native ligation of N-substituted glycine oligomers, or peptoids. ...