Phosphorylase purine nucleoside

Names

[ Name ]:
Phosphorylase purine nucleoside

[Synonym ]:
2-Chloro-4,5-diaminopyridine
3,4-Pyridinediamine, 6-chloro-
6-Chloro-3,4-diaminepyridine
6-chloropyridine-3,4-diamine
6-Chloro-3,4-diaminopyridine
3,4-Pyridinediamine,6-chloro
6-Chloro-3,4-pyridinediamine

Biological Activity

[Description]:

Purine nucleoside phosphorylase is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Bzowska A, et al. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
409.3±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₆ClN₃

[ Molecular Weight ]:
143.574

[ Flash Point ]:
201.3±27.3 °C

[ Exact Mass ]:
143.025024

[ PSA ]:
64.93000

[ LogP ]:
1.09

[ Appearance of Characters ]:
lyophilized powder

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.685

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
B

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...