Chymotrypsinogen

Names

[ Name ]:
Chymotrypsinogen

[Synonym ]:
EINECS 232-905-3

Biological Activity

[Description]:

Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Inflammation/Immunology

[In Vivo]

Chymotrypsinogen 因其解决炎症症状的能力而被用于组织修复[2]。

[References]

[1]. WALSH, KA, et, al. TRYPSINOGEN AND CHYMOTRYPSINOGEN AS HOMOLOGOUS PROTEINS. Proc Natl Acad Sci U S A. 1964 Oct;52(4):884-9.

[2]. González-Titos A, et, al. Trypsinogen and chymotrypsinogen: potent anti-tumor agents. Expert Opin Biol Ther. 2021 Dec;21(12):1609-1621.

Chemical & Physical Properties

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Protein adsorption, desorption, and aggregation mediated by solid-liquid interfaces.

J. Pharm. Sci. 104 , 1946-59, (2015)

Adsorption of proteins to solid-fluid interfaces is often empirically found to promote formation of soluble aggregates and larger, subvisible, and visible particles, but key stages in this process are...

Electrodynamic pressure modulation of protein stability in cosolvents.

Biochemistry 52(46) , 8363-73, (2013)

Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein foldin...

Pharmacological inhibition of PAR2 with the pepducin P2pal-18S protects mice against acute experimental biliary pancreatitis.

Am. J. Physiol. Gastrointest. Liver Physiol. 304(5) , G516-26, (2013)

Pancreatic acinar cells express proteinase-activated receptor-2 (PAR2) that is activated by trypsin-like serine proteases and has been shown to exert model-specific effects on the severity of experime...