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AMG1

Names

[ CAS No. ]:
903591-53-7

[ Name ]:
AMG1

[Synonym ]:
MFCD27924112
Benzamide, N-[5-[2-chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl]-2,6-difluoro-
N-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-pyrazinyl}-2,6-difluorobenzamide

Biological Activity

[Description]:

A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.

[References]

References 1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85. View Related Products by Target Calcium Channel

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
411.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H9ClF5N3O

[ Molecular Weight ]:
413.729

[ Flash Point ]:
202.4±28.7 °C

[ Exact Mass ]:
413.035431

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds