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(±)20-HDHA

Names

[ CAS No. ]:
90906-41-5

[ Name ]:
(±)20-HDHA

[Synonym ]:
4,7,10,13,16,18-Docosahexaenoic acid, 20-hydroxy-, (4Z,7Z,10Z,13Z,16Z,18E)-
(4Z,7Z,10Z,13Z,16Z,18E)-20-Hydroxy-4,7,10,13,16,18-docosahexaenoic acid

Biological Activity

[Description]:

(±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Numerous reports demonstrate the beneficial effects of fish oil on human diseases such as arthritis, Alzheimer’s disease, lung fibrosis, and inflammatory bowel diseases. As an essential omega-3 polyunsaturated fatty acid, Docosahexaenoic acid (DHA) is a major component of fish oil[3].

[References]

[1]. VanRollins M, et al. Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. J Lipid Res. 1984 May;25(5):507-17.

[2]. Kim HY, et al. Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. Prostaglandins. 1990 Nov;40(5):473-90.

[3]. Hong S, et al. Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom. 2007 Jan;18(1):128-44.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
500.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H32O3

[ Molecular Weight ]:
344.488

[ Flash Point ]:
270.4±26.6 °C

[ Exact Mass ]:
344.235138

[ PSA ]:
57.53000

[ LogP ]:
5.09

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.533

Related Compounds