MAL3-101

MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM; also exhibits antimyeloma effects on MM cell lines in vitro and in vivo in a xenograft plasmacytoma model, as well as on primary tumor cells and bone marrow endothelial cells from myeloma patients.

References 1. Fewell SW, et al. J Biol Chem. 2004 Dec 3;279(49):51131-40. 2. Huryn DM, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. 3. Braunstein MJ, et al. J Oncol. 2011;2011:232037. doi: 10.1155/2011/232037. View Related Products by Target Heat Shock Protein (HSP)