6-Phosphogluconic acid

Names

[ CAS No. ]:
921-62-0

[ Name ]:
6-Phosphogluconic acid

[Synonym ]:
6-PHOSPHOGLUCONIC ACID BARIUM SALT
EINECS 213-069-9
6-Phosphogluconate Barium Salt Hydrate
MFCD00066440
6-O-Phosphonohexonic acid
Hexonic acid, 6-(dihydrogen phosphate)

Biological Activity

[Description]:

6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

6-Phosphogluconic acid (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].

[References]

[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.

[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
774.8±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₃O₁₀P

[ Molecular Weight ]:
276.135

[ Flash Point ]:
422.4±35.7 °C

[ Exact Mass ]:
276.024628

[ PSA ]:
406.56000

[ LogP ]:
-3.25

[ Vapour Pressure ]:
0.0±6.0 mmHg at 25°C

[ Index of Refraction ]:
1.623

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332

[ Precautionary Statements ]:
P261-P301 + P312 + P330-P304 + P340 + P312

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/22

[ Safety Phrases ]:
28

[ RIDADR ]:
UN 1564 6.1/PG 3

[ Packaging Group ]:
III

Synthetic Route

Click to get detail synthetic route

Articles

Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity.

Biochem. J. 449(2) , 427-35, (2013)

Metabolic network reconstructions define metabolic information within a target organism and can therefore be used to address incomplete metabolic information. In the present study we used a computatio...

Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.

Cancer Cell 22(5) , 585-600, (2012)

It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in ...

A novel NADPH:(bound) NADP+ reductase and NADH:(bound) NADP+ transhydrogenase function in bovine liver catalase.

Biochem. J. 385(Pt 3) , 763-8, (2005)

Many catalases have the shared property of containing bound NADPH and being susceptible to inactivation by their own substrate, H2O2. The presence of additional (unbound) NADPH effectively prevents bo...