UHRF1 PHD inhibitor MLD4
Names
[ CAS No. ]:
922067-76-3
[ Name ]:
UHRF1 PHD inhibitor MLD4
Biological Activity
[Description]:
UHRF1 PHD inhibitor MLD4 is a specific compound that selectively inhibits the UHRF1-histone interaction (IC50=12.4 uM), targets the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.UHRF1 PHD inhibitor MLD4 inhibited binding between H3K9me3(FAM) and UHRF1 with IC50 of 24-26 uM, displace UHRF1-histone H3 binding in cells.
[References]
1. Wallace H Liu, et al. Biochemistry. 2022 Feb 10.
Chemical & Physical Properties
[ Molecular Formula ]:
C22H32N4O4
[ Molecular Weight ]:
416.522