H-D-Ala-D-Ala-OH

Names

[ CAS No. ]:
923-16-0

[ Name ]:
H-D-Ala-D-Ala-OH

[Synonym ]:
D-ALANYL-D-ALANINE
MFCD00066038
(R)-2-((R)-2-Aminopropanamido)propanoic acid
H-D-ALA-D-ALA-OH
D-ALA-D-ALA
D-Ala-D-Ala-OH

Biological Activity

[Description]:

D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite[1][2].

[Related Catalog]:

Research Areas >> Others

[Target]

Microbial Metabolite

[References]

[1]. Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106.

[2]. Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80.

Chemical & Physical Properties

[ Density]:
1.208 g/cm3

[ Boiling Point ]:
402.6ºC at 760 mmHg

[ Melting Point ]:
286 - 288ºC

[ Molecular Formula ]:
C₆H₁₂N₂O₃

[ Molecular Weight ]:
160.17100

[ Flash Point ]:
197.3ºC

[ Exact Mass ]:
160.08500

[ PSA ]:
92.42000

[ LogP ]:
0.01410

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.

Antimicrob. Agents Chemother. 58(9) , 5191-201, (2014)

Glycopeptides and β-lactams inhibit bacterial peptidoglycan synthesis in Gram-positive bacteria; resistance to these antibiotics is studied intensively in enterococci and staphylococci because of thei...

Bond dissociation of the dipeptide dialanine and its derivative alanine anhydride induced by low energy electrons.

J. Chem. Phys. 134(5) , 054305, (2011)

Dissociative electron attachment to dialanine and alanine anhydride has been studied in the gas phase utilizing a double focusing two sector field mass spectrometer. We show that low-energy electrons ...