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METHYL N-PROPYL NITROSAMINE

Names

[ CAS No. ]:
924-46-9

[ Name ]:
METHYL N-PROPYL NITROSAMINE

[Synonym ]:
Nitrosomethyl-n-propylamine
Methylpropylnitrosoamine
N-nitrosomethylpropylamine
PROPYLAMINE,N-METHYL-N-NITROSO
Salpetrigsaeure-methylpropylamid
N-Nitrosomethyl-N-propylamine
Nitrosomethylpropylamine
N-Methyl-N-propylnitrosamine
Methyl-nitroso-propyl-amin
Methylpropylnitrosamin
N-Nitroso-propyl-methylamin
N-Nitroso-methyl-n-propylamin
Methyl-n-propylnitrosamine
methyl-nitroso-propyl-amine
Methylpropylnitrosamine

Chemical & Physical Properties

[ Density]:
0.95 g/cm3

[ Boiling Point ]:
173.9ºC at 760mmHg

[ Molecular Formula ]:
C4H10N2O

[ Molecular Weight ]:
102.13500

[ Flash Point ]:
59ºC

[ Exact Mass ]:
102.07900

[ PSA ]:
32.67000

[ LogP ]:
1.00960

[ Index of Refraction ]:
1.442

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UI3850000
CHEMICAL NAME :
Propylamine, N-methyl-N-nitroso-
CAS REGISTRY NUMBER :
924-46-9
BEILSTEIN REFERENCE NO. :
1745070
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C4-H10-N2-O
MOLECULAR WEIGHT :
102.16
WISWESSER LINE NOTATION :
ONN3&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
106 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
77 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Blood - hemorrhage
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
160 mg/kg/23W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240 mg/kg/45W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
185 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
490 mg/kg/23W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Sense Organs and Special Senses (Olfaction) - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1250 mg/kg/24W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
100 mg/kg female 14 day(s) after conception
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
225 mg/kg/18W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
700 umol/L
REFERENCE :
50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology, Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%


Related Compounds