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AF-792

Names

[ CAS No. ]:
927872-24-0

[ Name ]:
AF-792

[Synonym ]:
2,4-Pyrimidinediamine, 5-[5-ethynyl-4-methoxy-2-(1-methylethyl)phenoxy]-
5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine

Biological Activity

[Description]:

AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo.

[References]

References 1. Carter DS, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31. 2. Kaan TK, et al. J Neurosci. 2010 Mar 24;30(12):4503-7. View Related Products by Target P2X Receptor

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
490.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H18N4O2

[ Molecular Weight ]:
298.340

[ Flash Point ]:
250.7±31.5 °C

[ Exact Mass ]:
298.142975

[ LogP ]:
2.36

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.620

Related Compounds