MK-1925

Names

[ Name ]:
MK-1925

Biological Activity

[Description]:

MK-1925 is a selective, orally active, brain-penetrant opioid receptor-like 1 (ORL1;NOP receptor) antagonist with binding IC50 of 8.2 nM; shows good selectivity over other opioid receptors and the hERG channel; exhibits in vivo antagonist activity against the reduction in locomotor activity induced by ORL1 agonist in mice.

[References]

References 1. Kobayashi K, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. View Related Products by Target Opioid Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁F₃N₄

[ Molecular Weight ]:
362.4

Related Compounds

TRPV1 antagonist 5
MK-8745
MK-0812 Succinate
MK-6240 Precursor
MK-2206 2HCl
MK-3697
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
N-({8-azabicyclo[3.2.1]octan-3-yl}methyl)-4-nitrobenzene-1-sulfonamide
1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclohexane-1-carboxylic acid
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2,6-Bis(propan-2-yl)imidazo[2,1-b][1,3]thiazole-5-sulfonyl chloride
(5-Bromo-2-methylphenyl)methanesulfonyl fluoride
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide