HMMNI

Names

[ CAS No. ]:
936-05-0

[ Name ]:
HMMNI

[Synonym ]:
1-Methyl-2-hydroxymethyl-5-nitroimidazole
imidazole-2-methanol, 1-methyl-5-nitro-
1-Methyl-5-nitro-1H-imidazole-2-methanol
2-hydroxymethyl-1-methyl-5-nitroimidazole
1H-Imidazole-2-methanol, 1-methyl-5-nitro-
(1-Methyl-5-nitro-1H-imidazol-2-yl)methanol

Biological Activity

[Description]:

HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Cronly M, et al. Rapid confirmatory method for the determination of 11 nitroimidazoles in egg using liquid chromatography tandem mass spectrometry. J Chromatogr A. 2009;1216(46):8101‐8109.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
388.0±22.0 °C at 760 mmHg

[ Melting Point ]:
110-112ºC

[ Molecular Formula ]:
C₅H₇N₃O₃

[ Molecular Weight ]:
157.127

[ Flash Point ]:
188.5±22.3 °C

[ Exact Mass ]:
157.048737

[ PSA ]:
83.87000

[ LogP ]:
-0.49

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI6801000

CHEMICAL NAME :: Imidazole-2-methanol, 1-methyl-5-nitro-

CAS REGISTRY NUMBER :: 936-05-0

BEILSTEIN REFERENCE NO. :: 0744944

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H7-N3-O3

MOLECULAR WEIGHT :: 157.15

WISWESSER LINE NOTATION :: T5N CNJ A1 B1Q ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 10 umol/L/20H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NI6801000

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Simultaneous determination of nitroimidazole residues in honey samples by high-performance liquid chromatography with ultraviolet detection.

J. AOAC Int. 90(3) , 872-8, (2007)

A rapid and sensitive high-performance liquid chromatography (LC) method was developed for the simultaneous determination of metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), tinidazole (TNZ...

Confirmation of four nitroimidazoles in porcine liver by liquid chromatography-tandem mass spectrometry.

Anal. Chim. Acta 586(1-2) , 394-8, (2007)

A sensitive and reliable multiresidue method is described for analysis of ronidazole, metronidazole, dimetridazole and the common metabolite of ronidazole and dimetridazole, 2-hydroxymethyl-1-methyl-5...

Pharmacokinetics and anti-trichomonal efficacy of a dimetridazole tablet and water-soluble powder in homing pigeons (Columba livia).

J. Vet. Pharmacol. Ther. 19(1) , 62-7, (1996)

The anti-trichomonal efficacy and pharmacokinetics of dimetridazole were investigated in the homing pigeon (Columba livia). Dimetridazole was formulated for drinking water medication and as a prolonge...