L-Azidohomoalanine hydrochloride

Names

[ Name ]:
L-Azidohomoalanine hydrochloride

[Synonym ]:
H-Dab(N3).HCl
26430 NGAMMA-AZIDO-L-2,4-DIAMINOBUTYRIC ACID
H-L-AHA-OH*HCL 4-AZIDO-L-HOMOALANINE, (S)-2-AMINO-4-AZIDOBUTANOIC ACID HYDROCHLORIDE
4-AZIDO-L-HOMOALANINE HYDROCHLORIDE
CLK-AA005-10 4-AZIDO-L-HOMOALANINE HCL, 10 MG PACK
4-Azido-L-homoalanine, (S)-2-Amino-4-azidobutanoic acid hydrochloride

Biological Activity

[Description]:

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄H₉ClN₄O₂

[ Molecular Weight ]:
180.59300

[ Exact Mass ]:
180.04100

[ PSA ]:
113.07000

[ LogP ]:
1.05376

Safety Information

[ HS Code ]:
2929909090

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%