Suc-Leu-Tyr-AMC
Names
[ CAS No. ]:
94367-20-1
[ Name ]:
Suc-Leu-Tyr-AMC
[Synonym ]:
CALPAIN SUBSTRATE II,FLUOROGENIC
N-SUCCINYL-LEU-TYR 4-METHYLCOUMARYL-7-AMIDE
succinyl-leucyl-tyrosyl-4-methyl-7-coumarylamide
N-SUCCINYL-LEU-TYR 7-AMIDO-4-METHYLCOUMARIN
CALPAIN SUBSTRATE I
SUC-LEU-TYR-AMC
SUC-LY-AMC
SUCCINYL-LEU-TYR-AMC
SUC-LEU-TYR-7-AMINO-4-METHYLCOUMARIN
MFCD00057900
Chemical & Physical Properties
[ Density]:
1.324g/cm3
[ Boiling Point ]:
945.5ºC at 760mmHg
[ Molecular Formula ]:
C29H33N3O8
[ Molecular Weight ]:
551.58800
[ Flash Point ]:
525.6ºC
[ Exact Mass ]:
551.22700
[ PSA ]:
175.04000
[ LogP ]:
3.72350
[ Index of Refraction ]:
1.611
[ Storage condition ]:
−20°C
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
J. Biol. Chem. 259 , 12489, (1984)
Homogeneous porcine calpain (Ca2+-dependent cysteine proteinase) was found to hydrolyze a variety of peptides and synthetic substrates. Leu-Trp-Met-Arg-Phe-Ala, eledoisin-related peptide, alpha-neoend...
Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin.Biochem. J. 248(2) , 589-94, (1987)
Inhibition of chicken calpain II by proteins of the cystatin superfamily and alpha 2-macroglobulin was investigated. Human liver cystatins A and B, human cystatin C, chicken cystatin and rat T-kininog...
Probing of primed and unprimed sites of calpains: Design, synthesis and evaluation of epoxysuccinyl-peptide derivatives as selective inhibitors.Eur. J. Med. Chem. 82 , 274-80, (2014)
Calpains are intracellular cysteine proteases with important physiological functions. Up- or downregulation of their expression can be responsible for several diseases, therefore specific calpain inhi...