3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile
Names
[ CAS No. ]:
946400-19-7
[ Name ]:
3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile
Biological Activity
[Description]:
3-chloro-4-[[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methyl-1-piperazinyl]sulfonyl]-Benzonitrile shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
[References]
1. Wan ZK, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem. 2009 Sep 10;52(17):5449-61.
Chemical & Physical Properties
[ Molecular Formula ]:
C19H16ClF4N3O2S
[ Molecular Weight ]:
461.86