<Suppliers Price>

J9

Names

[ CAS No. ]:
947018-15-7

[ Name ]:
J9

[Synonym ]:
2-Pyrimidinamine, 4-cyclopropyl-5-(4-pyridinyl)-
Glucocorticoid Resistance Inhibitor
MFCD11051713
4-Cyclopropyl-5-(4-pyridinyl)-2-pyrimidinamine

Biological Activity

[Description]:

J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Cantley AM, et al. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr 25;5(7):754-9.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
449.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H12N4

[ Molecular Weight ]:
212.251

[ Flash Point ]:
256.3±18.7 °C

[ Exact Mass ]:
212.106201

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.668

Related Compounds