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ABT-288

Names

[ CAS No. ]:
948845-91-8

[ Name ]:
ABT-288

[Synonym ]:
ABT-288
2-{4'-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-4-biphenylyl}-3(2H)-pyridazinone
3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]-
5MEI1M3NHH

Biological Activity

[Description]:

ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively; enhances the release of acetylcholine and dopamine in rat prefrontal cortex; possesses excellent pharmacokinetics and oral bioavailability.

[References]

References 1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45. 2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97. 3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74. View Related Products by Target Histamine Receptor

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
567.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H24N4O

[ Molecular Weight ]:
372.463

[ Flash Point ]:
296.9±32.9 °C

[ Exact Mass ]:
372.195007

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds