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2-Methoxyestrone-d4

Names

[ CAS No. ]:
949885-90-9

[ Name ]:
2-Methoxyestrone-d4

[Synonym ]:
2-METHOXYESTRONE-D4
2-Methoxyestrone-1,4,16,16-d4

Biological Activity

[Description]:

2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lewis KM, et al. pKa values of estrone, 17 beta-estradiol and 2-methoxyestrone. Steroids. 1979 Nov;34(5):485-99.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H20D4O3

[ Molecular Weight ]:
304.42

[ Exact Mass ]:
300.17300

[ PSA ]:
46.53000

[ LogP ]:
3.82600

Related Compounds