2-Methylindole

Names

[ CAS No. ]:
95-20-5

[ Name ]:
2-Methylindole

[Synonym ]:
2-Methylindole
EINECS 202-398-3
MFCD00005616
1H-Indole, 2-methyl-
2-Methyl-1H-indole

Biological Activity

[Description]:

2-Methylindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

2-甲基吲哚用作反应物，通过碘催化的马尔可夫尼科夫加成反应、Friedel-Crafts 烷基化反应区域选择性合成氧代吡咯烷类似物、制备色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚作为潜在的抗癌免疫调节剂、Michael 加成反应以及合成环氧合酶 1 (COX-1)/环氧合酶 2 (COX-2) 抑制剂。

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
272.0±0.0 °C at 760 mmHg

[ Melting Point ]:
57-59 °C(lit.)

[ Molecular Formula ]:
C₉H₉N

[ Molecular Weight ]:
131.17

[ Flash Point ]:
112.5±11.3 °C

[ Exact Mass ]:
131.073502

[ PSA ]:
15.79000

[ LogP ]:
2.60

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
Freezer (-20°C)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM0345000

CHEMICAL NAME :: 1H-Indole, 2-methyl-

CAS REGISTRY NUMBER :: 95-20-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H9-N

MOLECULAR WEIGHT :: 131.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >262 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1620,1974

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36/37-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NM0345000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Development of a quantitative method for the simultaneous analysis of the boar taint compounds androstenone, skatole and indole in porcine serum and plasma by means of ultra-high performance liquid chromatography coupled to high resolution mass spectrometry.

Food Chem. 187 , 120-9, (2015)

Boar taint is an off-odour occurring while heating meat or fat from boars. A method detecting the three compounds (androstenone, skatole and indole) simultaneously in blood would offer substantial adv...

The effect of skatole and androstenone on consumer response towards streaky bacon and pork belly roll.

Meat Science 110 , 52-61, (2015)

Consumer liking was assessed for streaky bacon and pork belly roll from entire male pigs with an androstenone (AND) content of up to 9.4 ppm and a skatole (SKA) content of up to 0.92 ppm in the back f...

Degradation of substituted indoles by an indole-degrading methanogenic consortium.

Appl. Environ. Microbiol. 57(9) , 2622-7, (1991)

Degradation of indole by an indole-degrading methanogenic consortium enriched from sewage sludge proceeded through a two-step hydroxylation pathway yielding oxindole and isatin. The ability of this co...