2-Chloroaniline

Names

[ CAS No. ]:
95-51-2

[ Name ]:
2-Chloroaniline

[Synonym ]:
Benzenamine, 2-chloro-
1-Chloro-2-aminobenzene
2-chlorophenylamine
2-chloro-aniline
2-Chloroanline
OCA
O-CHLOROANILINE D
2-CHLOROBENZAMINE
BENZENAMINE,2-CHLORO-
MFCD00007656
2-Chlorobenzenamine
ortho-chloroaniline
EINECS 202-426-4
2-CHLORO ANILINE
o-Chloraniline
ZR BG
1-Amino-2-chlorobenzene
2-Aminochlorobenzene
2-CHLOROANILINE FOR SYNTHESIS
o-chloro-anilin
o-Chloroaniline
2-CHLORANILIN
2-CHLOROANALINE

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
208.8±0.0 °C at 760 mmHg

[ Melting Point ]:
0-3 °C

[ Molecular Formula ]:
C₆H₆ClN

[ Molecular Weight ]:
127.572

[ Flash Point ]:
97.8±0.0 °C

[ Exact Mass ]:
127.018875

[ PSA ]:
26.02000

[ LogP ]:
1.91

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.598

[ Water Solubility ]:
5.13 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX0525000

CHEMICAL NAME :: Aniline, o-chloro-

CAS REGISTRY NUMBER :: 95-51-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C6-H6-Cl-N

MOLECULAR WEIGHT :: 127.58

WISWESSER LINE NOTATION :: ZR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 256 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 310 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14560 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14560 mg/kg/13W-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 600 ug/L

REFERENCE :: BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83962 No. of Facilities: 38 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 18138 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H319-H373-H410

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310 + P330-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/24/25;R33;R50/53

[ Safety Phrases ]:
S28-S36/37-S45-S60-S61-S28A

[ RIDADR ]:
UN 2019 6.1/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
BX0525000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

J. Chromatogr. A. 1356 , 221-9, (2014)

For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

Biodegradation of 2-chloroaniline, 3-chloroaniline, and 4-chloroaniline by a novel strain Delftia tsuruhatensis H1.

J. Hazard. Mater. 179(1-3) , 875-82, (2010)

A new strain Delftia tsuruhatensis H1 able to degrade several chloroanilines (CAs) as individual compounds or a mixture was isolated from a CA-degrading mixed bacterial culture. The isolated strain co...

Biodegradability of chlorinated anilines in waters.

Biomed. Environ. Sci. 20(2) , 141-5, (2007)

To identify the bacteria tolerating chlorinated anilines and to study the biodegradability of o-chloroaniline and its coexistent compounds.Microbial community of complex bacteria was identified by pla...