2'-Deoxycytidine monohydrate

Names

[ CAS No. ]:
951-77-9

[ Name ]:
2'-Deoxycytidine monohydrate

[Synonym ]:
1-(2-Deoxy-β-D-ribofuranosyl)cytosine
EINECS 213-454-1
4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone
4-Amino-1-(2-deoxy-β-D-glycero-pentofuranosyl)pyrimidin-2(1H)-one
2-pyrimidinol, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,4-dihydro-4-imino-
Cytidine, 2'-deoxy-
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-imino-1,4-dihydro-2-pyrimidinol
1-(2-Deoxy-b-D-ribofuranosyl)cytosine
deoxycytidine
2'-Deoxycytidine monohydrate
4-Amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone
2(1H)-pyrimidinone, 4-amino-1-(2-deoxy-β-D-glycero-pentofuranosyl)-
2‘-Deoxycytidine
1-(2-deoxy-β-D-erythro-pentofuranosyl)-Cytosine
MFCD00006547

Biological Activity

[Description]:

2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).

[Related Catalog]:

Natural Products >> Saccharides and Glycosides

Research Areas >> Others

[Target]

Human Endogenous Metabolite

Brdu

[References]

[1]. Horn D, et al. Inhibition of biological effects of bromodeoxyuridine by deoxycytidine: correlation with decreased incorporation of bromodeoxyuridine into DNA. Somatic Cell Genet. 1976 Sep;2(5):469-81.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
482.1±55.0 °C at 760 mmHg

[ Melting Point ]:
209-211 °C(lit.)

[ Molecular Formula ]:
C₉H₁₃N₃O₄

[ Molecular Weight ]:
227.22

[ Flash Point ]:
245.4±31.5 °C

[ PSA ]:
119.83000

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA3800000

CHEMICAL NAME :: Cytidine, 2'-deoxy-

CAS REGISTRY NUMBER :: 951-77-9

BEILSTEIN REFERENCE NO. :: 0087567

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H13-N3-O4

MOLECULAR WEIGHT :: 227.25

WISWESSER LINE NOTATION :: T6NVNJ DZ A- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 800 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HA3800000

Precursor & DownStream

Precursor

DownStream

Articles

Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry.

Anal. Bioanal. Chem 407(13) , 3693-704, (2015)

Nucleosides and nucleoside triphosphates are the building blocks of nucleic acids and important bioactive metabolites, existing in all living cells. In the present study, two liquid chromatography tan...

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.

Bioorg. Med. Chem. 16 , 3866-70, (2008)

Thymidine phosphorylase (TP, EC 2.4.2.4) recognized the structure of the substrate with high specificity, via both the base and the ribosyl moieties. The replacement of 3'-OH of thymidine markedly inf...