2'-deoxyuridine

Names

[ CAS No. ]:
951-78-0

[ Name ]:
2'-deoxyuridine

[Synonym ]:
Uracildeoxyr
deoxyuridine
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone
T6NVMVJ A- ET5OTJ B1Q CQ &&Ribo-β-D Form
2'-deoxy-uridin
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-
1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
[131I]-Deoxyuridine
2'-Deoxyuridine
Desoxyuridine
Uridine, 2'-deoxy-
MFCD00006527
2'-dU
EINECS 213-455-7
1-(2-Deoxy-D-erythro-pentofuranosyl)uracil
Deoxyribose uracil
1-(2-deoxy-β-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
Deoxy-uridin
2′-Deoxyuridine
2(1H)-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-
[3H]-Deoxyuridine
1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil
1-(2-deoxy-β-δ-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
durd
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-ribofuranosyl)-
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
1-(2-deoxy-β-δ-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione
DEOXYURIDINE-2'
1-(2-deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione
1-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dion
2'-DEOXYTHYMIDINE-5'-DIPHOSPHATE TRISODIUM SALT
1-(2-Deoxy-δ-erythro-pentofuranosyl)uracil

Biological Activity

[Description]:

2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

[Related Catalog]:

Research Areas >> Infection

Natural Products >> Saccharides and Glycosides

[Target]

Human Endogenous Metabolite

[References]

[1]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Melting Point ]:
167-169 °C(lit.)

[ Molecular Formula ]:
C₉H₁₂N₂O₅

[ Molecular Weight ]:
228.202

[ Exact Mass ]:
228.074615

[ PSA ]:
104.55000

[ LogP ]:
-1.70

[ Index of Refraction ]:
1.603

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
300 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7490000

CHEMICAL NAME :: Uridine, 2'-deoxy-

CAS REGISTRY NUMBER :: 951-78-0

BEILSTEIN REFERENCE NO. :: 0024433

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H12-N2-O5

MOLECULAR WEIGHT :: 228.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YU7490000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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