7-Azido-4-methylcoumarin

Names

[ Name ]:
7-Azido-4-methylcoumarin

[Synonym ]:
MFCD16652405

Biological Activity

[Description]:

7-Azido-4-methylcoumarin is a fluorescent hydrogen sulfide (H2S) probe. 7-Azido-4-methylcoumarin serves as a highly sensitive assay for cystathionine β-synthase activity[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Megan K Thorson, et al. Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe. Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4641-4.

Chemical & Physical Properties

[ Melting Point ]:
117.8°C (lit.)

[ Molecular Formula ]:
C₁₀H₇N₃O₂

[ Molecular Weight ]:
201.18100

[ Exact Mass ]:
201.05400

[ PSA ]:
79.96000

[ LogP ]:
2.49596

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues.

Analyst 138 , 946-51, (2013)

A coumarin-based fluorescence chemoprobe was developed and evaluated for the selective and sensitive detection of hydrogen sulfide in degassed PBS buffers and fetal bovine serum. Fluorescence detectio...

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe.

Angew. Chem. Int. Ed. Engl. 52(17) , 4641-4644, (2013)

Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for th...