Antimalarial agent 15

Names

[ CAS No. ]:
956928-33-9

[ Name ]:
Antimalarial agent 15

Biological Activity

[Description]:

Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC50=20 nM)[1].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

IC50: 20 nM (P. falciparum 3D7)[1]


[In Vitro]

Antimalarial agent 15 shows no cytotoxicity against mammalian cells or affects the growth of bacteria and fungi up to 30 μM[1].

[References]

[1]. Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:116830.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H30N2O6

[ Molecular Weight ]:
502.56

Related Compounds