Charybdotoxin

Names

[ Name ]:
Charybdotoxin

[Synonym ]:
MFCD00146378

Biological Activity

[Description]:

Charybdotoxin, a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, is a K+ channel blocker[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Charybdotoxin represents a remarkable tool for studying K+ channels[1].

[References]

[1]. M L Garcia , et al. Charybdotoxin and its effects on potassium channels. Am J Physiol. 1995 Jul;269(1 Pt 1):C1-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇₆H₂₇₇N₅₇O₅₅S₇

[ Molecular Weight ]:
4295.89

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Triclosan, an environmental pollutant from health care products, evokes charybdotoxin-sensitive hyperpolarization in rat thymocytes.

Environ. Toxicol. Pharmacol. 32(3) , 417-22, (2011)

The effects of triclosan, an environmental pollutant from household items and health care products, on membrane potential and intracellular Ca(2+) concentrations of rat thymocytes were examined by a f...

Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.

Life Sci. 92(23) , 1131-7, (2013)

Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfu...

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.

Am. J. Physiol. Lung Cell. Mol. Physiol. 303(11) , L956-66, (2012)

Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information on the effects of bitter taste agonists ...