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deoxynyboquinone

Names

[ CAS No. ]:
96748-86-6

[ Name ]:
deoxynyboquinone

[Synonym ]:
1,4,6-Trimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone
Pyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone, 1,4,6-trimethyl-
deoxynyboquinone

Biological Activity

[Description]:

Deoxynyboquinone (NSC 165572;DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1); it's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).

[References]

References 1. Bair JS, et al. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. 2. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47. 3. Lee HY, et al. ACS Chem Biol. 2017 May 19;12(5):1416-1424. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
591.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H12N2O4

[ Molecular Weight ]:
284.267

[ Flash Point ]:
311.4±30.1 °C

[ Exact Mass ]:
284.079712

[ LogP ]:
-0.41

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds