Adipokinetic Hormone II (Locusta migratoria)

Names

[ CAS No. ]:
98968-94-6

[ Name ]:
Adipokinetic Hormone II (Locusta migratoria)

[Synonym ]:
Chromatophorotropin, red-pigment-concentrating (Pandalus borealis) 6-L-alanine-
ADIPOKINETIC HORMONE II (LOCUSTA MIGRATORIA)
Lom-AKH-2
ADIPOKINETIC HORMONE II
Adipokinetic hormone II (Locusta migratoria)
Locust adipokinetic hormone II
Lom-AKH-II

Biological Activity

[Description]:

Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs)[1][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Adipokinetic hormone II (Locusta migratoria) (radiolabeled; 1 pmol in 10 μL of 10% methanol; 30 min on ice, and repeated for 2 h at 30 ℃) shows no association with one of the larger protein components, indicating a lack of separate transporting or carrier protein in the hemolymph[1]. Adipokinetic hormones (AKHs) are known to be involved in insect immunity and shows the mechanism of metabolic stimulation, leading a significant increase in carbon dioxide production, and efficacy increase of toxins produced by I. fumosorosea in the cockroach's body[2]. Adipokinetic hormone II is more effective than hormone I in bringing about an accumulation of cAMP in the fat body[4].

[In Vivo]

Adipokinetic hormone II (Locusta migratoria) (1 pmol in 10 μL of 10% methanol; injection) plays its own biol. role in the overall syndrome of insect flight, with different half-lives of 40 min and 37 min during rest and flight, respectively[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C43H57N11O11

[ Molecular Weight ]:
903.98000

[ Exact Mass ]:
903.42400

[ PSA ]:
355.00000

[ LogP ]:
1.14140

Related Compounds