1-(4-Chlorophenyl)ethanone
Names
[ CAS No. ]:
99-91-2
[ Name ]:
1-(4-Chlorophenyl)ethanone
[Synonym ]:
4-acetylchlorobenzene
P-CHLOROACETOPHENONE
MFCD00000622
1-(4-chlorophenyl)ethan-1-one
1-(4-Chlorophenyl)ethanone
EINECS 202-800-7
4′-Chloroacetophenone
Acetophenone, 4'-chloro-
CHLOROACETOPHENONE-4
Acetophenone, 4'-chloro- (8CI)
4-Chloroacetophenone
4'-Chloroacetophenone
4-chlorophenyl methyl ketone
p-Chloracetophenone
usafdo-1
para-chloroacetophenone
Ethanone, 1-(4-chlorophenyl)-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
237.7±13.0 °C at 760 mmHg
[ Melting Point ]:
74-76 °C(lit.)
[ Molecular Formula ]:
C8H7ClO
[ Molecular Weight ]:
154.594
[ Flash Point ]:
107.1±11.0 °C
[ Exact Mass ]:
154.018539
[ PSA ]:
17.07000
[ LogP ]:
2.35
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.532
[ Water Solubility ]:
111 mg/L (25 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KM5600000
- CHEMICAL NAME :
- Ethanone, 1-(4-chlorophenyl)-
- CAS REGISTRY NUMBER :
- 99-91-2
- BEILSTEIN REFERENCE NO. :
- 0386014
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C8-H7-Cl-O
- MOLECULAR WEIGHT :
- 154.60
- WISWESSER LINE NOTATION :
- GR DV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1 mg/m3/1M
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- REFERENCE :
- 27ZZA9 "Manual of Pharmacology and Its Applications to Therapeutics and Toxicology," 8th ed., Sollman, T., Philadelphia, W.B. Saunders Co., 1957 Volume(issue)/page/year: 8,192,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1207 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,317,1976
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1752 mg/m3/15M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,411,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 87600 ug/m3/15M/10D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Endocrine - hyperglycemia Endocrine - changes in spleen weight
- REFERENCE :
- JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 14,411,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7067 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H315-H318-H330-H335
[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+,Xn
[ Risk Phrases ]:
R26;R36/37/38
[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A
[ RIDADR ]:
UN 3416 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
KM5600000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29147090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
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