<Suppliers Price>

24-Norursodeoxycholic acid

Names

[ CAS No. ]:
99697-24-2

[ Name ]:
24-Norursodeoxycholic acid

[Synonym ]:
24-norursodeoxycholic acid
3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic acid
Norursodeoxycholic acid
24-Norursodeoxycholic acid
24-Nor Ursodeoxycholic Acid

Biological Activity

[Description]:

24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels[1].

[References]

[1]. Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130(2):465-81.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.142±0.06 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
536.7±25.0 °C (760 mmHg)

[ Molecular Formula ]:
C23H38O4

[ Molecular Weight ]:
378.54500

[ Exact Mass ]:
378.27700

[ PSA ]:
77.76000

[ LogP ]:
4.08780

[ Storage condition ]:
2-8℃

Related Compounds