Temephos-d12

Names

[ CAS No. ]:
1219795-39-7

[ Name ]:
Temephos-d12

[Synonym ]:
O,O,O',O'-Tetrakis[(H)methyl] O,O'-(sulfanediyldi-4,1-phenylene) bis(phosphorothioate)
Phosphorothioic acid, O,O,O',O'-tetramethyl-d O,O'-(thiodi-4,1-phenylene) ester

Biological Activity

[Description]:

Temephos-d12 is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Thirugnanam M, et al. Environmental impact of mosquito pesticides: influence of temefos on the brain acetylcholinesterase of killifish. Environ Physiol Biochem. 1975;5(6):451-9.  

[3]. Wirth MC, et al. Selection and characterization of temephos resistance in a population of Aedes aegypti from Tortola, British Virgin Islands. J Am Mosq Control Assoc. 1999 Sep15(3):315-20.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
518.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H8D12O6P2S3

[ Molecular Weight ]:
478.543

[ Flash Point ]:
267.4±32.9 °C

[ Exact Mass ]:
478.065033

[ LogP ]:
5.96

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.613

Related Compounds