Arachidic acid-d4

Arachidic acid-d4 is the deuterium labeled Arachidic acid. Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Koppová I, et al. Analysis of fatty acid composition of anaerobic rumen fungi. Folia Microbiol (Praha). 2008;53(3):217-20.

[3]. Martin SA, et al. The discovery and early structural studies of arachidonic acid. J Lipid Res. 2016 Jul;57(7):1126-32.