2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
Names
[ CAS No. ]:
1223-36-5
[ Name ]:
2-(4-chlorophenoxy)-N-[2-(diethylamino)ethyl]acetamide
[Synonym ]:
ANP 246
Clofexamide
EINECS 214-951-6
IEM 455
Amichlophene
Chlofexamide
NP 246
4-Chlorphenoxyessigsaeure-<2-diethylaminoethylamid>
Chemical & Physical Properties
[ Density]:
1.12g/cm3
[ Boiling Point ]:
449.7ºC at 760 mmHg
[ Molecular Formula ]:
C14H21ClN2O2
[ Molecular Weight ]:
284.78200
[ Flash Point ]:
225.8ºC
[ Exact Mass ]:
284.12900
[ PSA ]:
41.57000
[ LogP ]:
2.56770
[ Vapour Pressure ]:
2.81E-08mmHg at 25°C
[ Index of Refraction ]:
1.522
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AB5822500
- CHEMICAL NAME :
- Acetamide, 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 1223-36-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C14-H21-Cl-N2-O2
- MOLECULAR WEIGHT :
- 284.82
- WISWESSER LINE NOTATION :
- GR DO1VM2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1040 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,935,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 1,444,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 290 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,154,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 167 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2702M
Safety Information
[ HS Code ]:
2924299090
Synthetic Route
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%