3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine

Names

[ Name ]:
3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine

[Synonym ]:
N-Desmethylchlorpromazine
NOR1-CHLORPROMAZINE
10H-Phenothiazine-10-propanamine,2-chloro-N-methyl
UNII-O1G7LW1I5H
Norchlorpromazine
Chlorpromazine impurity D
2-chloro-N-methyl-10H-phenothiazine-10-propanamine
N-Monodesmethylchlorpromazine
N-(3-methylaminopropyl)-2-chlorophenothiazine
[3-(2-chloro-phenothiazin-10-yl)-propyl]-methyl-amine

Chemical & Physical Properties

[ Density]:
1.229g/cm3

[ Boiling Point ]:
458.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₇ClN₂S

[ Molecular Weight ]:
304.83800

[ Flash Point ]:
230.9ºC

[ Exact Mass ]:
304.08000

[ PSA ]:
40.57000

[ LogP ]:
5.00810

[ Vapour Pressure ]:
1.4E-08mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ HS Code ]:
2934300000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Prediction of drug responses in schizophrenia: a method using a test dose of chlorpromazine.

Psychiatry Clin. Neurosci. 51(4) , 217-22, (1997)

Thirty-seven newly admitted schizophrenic patients were treated with an open and flexible dosage of chlorpromazine for 3 months after receiving a test dose. Levels of chlorpromazine, demethylated chlo...

Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.

Psychopharmacology 73(1) , 55-62, (1981)

Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during...

[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].

Boll. Soc. Ital. Biol. Sper. 60(9) , 1757-63, (1984)

Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The ...