Ro 19-1400

Names

[ CAS No. ]:
122937-55-7

[ Name ]:
Ro 19-1400

[Synonym ]:
3-(4-(2-((Methoxycarbonyl)oxy)-3-(((octadecylamino)carbonyl)oxy)propoxy)-4-oxobutyl)-,hydroxide,(R)-thiazolium
Thiazolium,3-(4-(2-((methoxycarbonyl)oxy)-3-(((octadecylamino)carbonyl)oxy)propoxy)-4-oxobutyl)-,hydroxide,(R)
Ro-19-1400
[(2R)-2-methoxycarbonyloxy-3-(octadecylcarbamoyloxy)propyl] 4-(1,3-thiazol-3-ium-3-yl)butanoate hydroxide

Biological Activity

[Description]:

Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. M. Pretolani, et al. Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs.Br J Pharmacol. 1989 Jun; 97(2): 433–442.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H56N2O8S

[ Molecular Weight ]:
616.85000

[ Exact Mass ]:
616.37600

[ PSA ]:
147.83000

[ LogP ]:
7.51090

Related Compounds