Plm IV inhibitor-2

Names

[ CAS No. ]:
1539276-38-4

[ Name ]:
Plm IV inhibitor-2

Biological Activity

[Description]:

Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC50 values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

Plm IV:24 nM (IC50)

Plm II:70 nM (IC50)

Plm I:0.3 μM (IC50)


[References]

[1]. Jaudzems K, et al. Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit. ACS Med Chem Lett. 2014 Jan 13;5(4):373-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H54N4O4

[ Molecular Weight ]:
642.87

Related Compounds