(Glu20)-Amyloid β-Protein (1-42)

Names

[ CAS No. ]:
1802086-22-1

[ Name ]:
(Glu20)-Amyloid β-Protein (1-42)

Biological Activity

[Description]:

(Glu20)-Amyloid β-Protein (1-42) is a slower fibrillizing variant of amyloid β-protein (Aβ). The Glu20 mutation reduces the aggregation propensity of Aβ42 and prevents accumulation of the slowly fibrillizing peptide. Amyloid β-protein is the primary component of both vascular and parenchymal amyloid deposits in Alzheimer's disease[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Poduslo JF, et al. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun;6(3):190-9.  

[2]. Williams TL, et al. The effect of Alzheimer's Aβ aggregation state on the permeation of biomimetic lipid vesicles. Langmuir. 2010 Nov 16;26(22):17260-8.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds